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In vitro evaluation of the anti-inflammatory effects of the traditionally known as anti-diabetes medicinal plant Asparagus aphyllus in primary isolated human peripheral blood mononuclear cells

Project Summary: 

Many metabolic diseases including, but not limited to, diabetes and obesity are accompanied by low grade inflammatory. In the case of diabetes type II, which is a complex metabolic disease that result in the development of impaired insulin signaling and β-cell dysfunction, insulin resistance, sub-clinical inflammation and increased oxidative stress are observed.  Pro-inflammatory cytokines (in particular TNF-a) are involved in insulin resistance. Therefore, successful diabetes prevention/treatment managements have to take these inflammatory process into account. In recent decades, a number of epidemiological investigations have shown that diet rich in foods with high-content of phytochemicals, and high total antioxidant capacity may be related to lower risk of diabetes and predisposing factors. Based on Greco-Arab and Islamic medicine and our recently published data, Asparagus aphyllus-L extracts represents a potential candidate for the development of diabetes herbal-based therapy. The aim of the proposed study is to confirm the anti-inflammatory effects of the traditionally known anti-diabetes plant Asparagus aphyllus-L and to go a step forward in identification of the responsible active compound/s. Therefore, we plan to test the effects of Asparagus aphyllus-L extracts (methanol, hexane and dichloromethane extracts) in primary isolated human peripheral blood mononuclear cells (PBMNCs).