Degree:
Master
Journal Name:
N/A
Volume:
1
Issue:
1
Pages From:
1
To:
1
Date:
Tuesday, January 1, 2013
Abstract:
The spreading of cancer is increasing over the world and the
percentage of deaths caused by this fatal disease is rising especially in the
developing countries. Scientists and researchers are now giving more of
their attention to the herbal medicine to provide treatment for more difficult
diseases like cancer due to the fact that the treatments of cancer patients
with chemical therapy have serious side effects. Recently herbal medicines
are coming to play a more vital role in the reduction and prevention of
cancer. The rapid interest in traditional Arabic herbal medicine (TAHM)
worldwide stimulated by many factors mainly, that herbal products are safe
and economical.
This current study investigates traditional Arabic Herbal Medicine
the in vitro cytotoxic and cytostatic of anticancer medicinal plants. Two
medicinal plant extracts, Cyclamen persicum corm and Quercus
calliprinos, were prepared using ethanol in water from the leaves of plants,
barks and fruits. The selection of these plants was done based on recent
survey that revealed their medicinal value in the treatment of cancer. The
ethanolic extracts were screened for cytostatic effects against healthy
mouse macrophages and both cytotoxic and cytostatic activities against
xiii
three cancer cell lines (human lung: fibroblast, mouse -macrophage Raw
264-7, human prostate: cell line PC3) using MTT test. C. persicum corm
extracts showed cytotoxicity for normal and all three cancer cell lines
tested at concentrations than 62.5µg/ml. In comparison to C. persicum all
three Q. calliprinos extracts showed lower cytotoxicity at all tested
concentrations. It is concluded that, for these medicinal plants, the
traditional uses as antitumor effects are the result may be of cytotoxic but
not of cytostatic properties of these plants.